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7 Best Fish Oil Supplements For Cholesterol: According To Dietitians

High cholesterol got you down? Find the best fish oil supplements in this guide! Get your heart happy & healthy again!
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Finding the best fish oil supplement for cholesterol management is crucial for those looking to improve their heart health through natural means. Fish oil supplements are renowned for their ability to support cardiovascular health, primarily by influencing cholesterol levels. In 2024, the selection of fish oil supplements has expanded, offering various options tailored to individual health needs. This guide will navigate you through the top choices, ensuring you select the best fish oil supplement for cholesterol improvement.

Best Fish Oil Supplements For Cholesterol: Quick Look

  1. Overall Best Fish Oil Supplement: Riti
  2. Best Fish Oil Supplement For Heart Health: Life Extension
  3. Ideal For Supporting Cognitive Function & Promoting Eye Health: Care/Of
  4. Popular Fish Oil Supplement In Liquid & Gummy Form: Nordic
  5. Best Fish Oil To Lower Cholesterol: Puritan’s Pride
  6. High-Quality Fish Oil Derived From The Tissue Of Oily Fish: Nature Made
  7. Best For A Budget With Subscription Benefits: VitaMedica

#1. Overall Best Fish Oil Supplement: Riti

       Riti Omega-3 Fish Oil Softgels emerge as a top choice for wellness, meticulously crafted to enhance heart health by maintaining cholesterol levels, cognitive function, and joint flexibility. Each softgel is a powerhouse of EPA and DHA, the pivotal omega-3 fatty acids renowned for their anti-inflammatory properties and vital roles in brain and cardiovascular health, further ensuring that you have good cholesterol in your body. Sourced from 100% wild-caught anchovies, Riti ensures a sustainable and high-quality omega-3 supply, encapsulated in a lemon-flavored softgel that eradicates the common fishy aftertaste. 

       Committed to purity and safety, Riti’s product undergoes rigorous third-party testing, guaranteeing a non-GMO, gluten-free, and artificial additive-free supplement. This dedication to quality and sustainability positions Riti Omega-3 Fish Oil Softgels as a superior choice for those seeking to support their well-being and lead a vibrant, health-oriented lifestyle.

 Product Details: 

  • Form: Softgel
  • Type: Triglyceride
  • Dose: 1 softgels
  • EPA per Serving: 432 mg
  • DHA per Serving: 268 mg
  • Other Ingredients: Gelatin, Glycerol, Water, Natural Lemon Flavour
  • Third-Party Tested: Yes


  • Subscription Offers: Discount of 15% on first purchase
  • Gluten-Free
  • Free from Genetic Modification
  • Lemon flavor for a good aftertaste
  • Higher amount of EPA and DHA per serving 


  • Allergen sensitivity for individuals with medical conditions

=> Click here to visit the official website “Riti”

#2. Best Fish Oil Supplement For Heart Health: Life Extension


Life Extension’s Super Omega-3 EPA/DHA with Sesame Lignans & Olive Extract stands at the forefront of nutritional innovation, offering a unique blend of heart-healthy omega-3 fatty acids, enhanced with the added benefits of sesame lignans and olive extract. 

By incorporating EPA and DHA, this supplement aids in maintaining optimal cholesterol levels and promoting overall heart health. This advanced formula is designed to support cardiovascular health, cognitive function, and inflammatory response. 

Life Extension’s commitment to purity and potency is evident in its rigorous third-party testing, ensuring that each batch meets the highest standards for quality and efficacy. This product is a testament to Life Extension’s dedication to extending the healthy life span of its customers through scientifically based, high-quality nutritional supplements.

Product Details: 

Form: Softgel

Type: Triglycerid`e

Dose: 2 softgels

EPA per Serving: 500 mg

DHA per Serving: 700 mg

Other Ingredients: highly refined fish oil concentrate (anchovy, mackerel, sardine), gelatin, glycerin, purified water, silica, beeswax, caramel color, natural flavor, sunflower lecithin, mixed tocopherols, maltodextrin, rosemary extract.

Third-Party Tested: Yes, The International Fish Oil Standard(IFOS) gave a 5 star rating to the product.


  • Subscription Benefits: AutoShipping and Save gives a 15% discount on the product price
  • Scientifically sound
  • Gluten-Exempt
  • GMO safe
  • Sesame lignans enhance the health benefits of fish oil and prevent preoxidation.
  • Olive extract delivers the health-promoting polyphenols found in olives, ensuring optimal benefits. 


  • May interact with medications such as blood thinners.

 => Click here to visit the official website “Life Extension”

#3. Ideal For Supporting Cognitive Function & Promoting Eye Health: Care/Of 


CARE/OF’s Fish Oil Supplement is a testament to the brand’s commitment to health, sustainability, and scientific backing. Each pill is packed with 800mg of omega-3 fatty acids, including 750mg of EPA and DHA, essential nutrients for maintaining cholesterol levels, supporting cognitive function, and promoting eye health. 

Sourced from non-GMO, wild-caught fish, CARE/OF emphasizes the importance of sustainability by adhering to Friend of the Sea® certification standards, ensuring their products respect and protect marine environments. The supplement is designed for those who may not get enough fish in their diet, providing a month’s supply of essential nutrients. 

Product Details: 

Form: Softgel

Dose: 1 softgels

EPA per Serving: 500 mg

DHA per Serving: 250 mg

Other Ingredients: Fish Oil, Softgel (Gelatin [Bovine], Glycerin), Mixed Tocopherols (to preserve freshness)

Third-Party Tested: Yes, certified by Friend of the Sea®, guaranteeing adherence to international standards for traceability, social accountability, and sustainable fishing practices set by the World Sustainability Organization  


  • Sustainable approach
  • Celiac-Friendly
  • Not Genetically Altered
  • Processed for Potency
  • Price on the lower side 


  • Fishy aftertaste and may also cause gastrointestinal issues

=> Click here to visit the official website “Care/Of”

#4. Popular Fish Oil Supplement In Liquid & Gummy Form: Nordic Naturals


Nordic Naturals Ultimate Omega stands as a pinnacle of excellence in the omega-3 supplement market, delivering unparalleled support for heart, brain, and overall wellness. Esteemed as one of the best omega-3 in the U.S., this product is meticulously crafted from 100% wild-caught sardines and anchovies, ensuring a pure and sustainable source of essential nutrients required to manage the good cholesterol in the human body. Each serving, whether in soft gel or liquid form, is packed with a potent dose of omega-3s, offering 1280 mg in soft gels and 2840 mg in liquid, to meet and exceed health and wellness needs.

Renowned for its fresh lemon taste, Ultimate Omega eliminates the common deterrent of fishy aftertaste, making daily supplementation a pleasant experience. This commitment to quality and palatability has garnered over 10 industry awards, including Delicious Living’s Best Omega-3, attesting to its superior formulation and consumer satisfaction.

Product Details: 

Forms: Available in Softgel, Liquid and Gummies

Type: Triglyceride

Dose: 2 softgels/One-half to one teaspoon daily/2 gummies

EPA per Serving: 600 mg

DHA per Serving: 450 mg

Other Ingredients: Purified deep sea fish oil (from anchovies and sardines), purified water, xylitol, fish gelatin, erythritol, glycerol, sodium citrate, natural flavors, gum arabic, citric acid, ascorbic acid, paprika extract (for color), stevia.

Third-Party Tested: Yes,By IGEN(Ingredient Identity Genetic Evaluation)


  • Subscription Benefits: Subscribe and save 10%
  • Wheat-Free
  • GMO Absent
  • Free Shipping on all orders
  • Available in 3 options: gummies, softgel and liquid


  • Contains added sugar

=> Click here to visit the official website “Nordic Naturals”

#5. Best Fish Oil To Lower Cholesterol: Puritan’s Pride


Puritan’s Pride Fish Oil Plus Cholesterol Support is meticulously designed to offer a dual-action formula that not only supports cardiovascular health but also aids in maintaining healthy cholesterol levels. Each softgel is packed with high-quality omega-3 fatty acids, EPA, and DHA, which are essential for heart health, reducing inflammation, and promoting overall well-being. What sets this supplement apart is its additional cholesterol support, likely formulated with natural ingredients known to assist in managing cholesterol levels.

Product Details:

Form: Softgel

Type: Triglyceride

Dose: 2 softgels

Omega-3 fatty acids:300mg

Plant sterols: 500mg per serving

Other Ingredients: Gelatin, Vegetable Glycerin. Contains <2% of Mixed Natural Tocopherols, Natural Caramel Color. Contains fish (anchovy, herring, mackerel, sardine) ingredients

Third-party Tested: Yes


  • Offers: 66.67% discount on buying products
  • Plant sterols of 500mg per serving
  • No Gluten
  • Non-Genetically engineered
  • Sustainably harvested
  • Guaranteed purity 


  • Allergy reactions may occur if consuming other medications.

=> Click here to visit the official website “Puritan’s Pride” 

#6. High-Quality Fish Oil Derived From The Tissue Of Oily Fish: Nature Made 

Nature Made’s collection of Fish Oil and Omega-3 supplements is designed with heart health, and management of good cholesterol at its core, offering a range of products to support cardiovascular wellness, brain health, and visual acuity. Recognized for their high-quality standards, Nature Made’s supplements provide essential omega-3 fatty acids, EPA, and DHA, derived from the oil contained in the tissue of oily fish. These polyunsaturated fats are crucial for maintaining a healthy heart, supporting brain function, and preserving eye health.

Product Details: 

Form: Softgel

Type: Triglyceride

Dose: 2 softgels

EPA and per Serving: 600 mg

Other Ingredients: Gelatin, glycerin, and tocopherols

Third-party Tested: Yes, by United States Pharmacopeia (USP).


  • Offers:25% discount on first purchase
  • Gluten-free
  • No Artificial Flavors
  • No Color Added 
  • Encapsulated and quality tested in the USA


  • Fishy aftertaste
  • Gastrointestinal reaction

=> Click here to visit the official website “Nature Made”

#7. Best For A Budget With Subscription Benefits: VitaMedica

VitaMedica’s Super EPA/DHA Fish Oil is a premium supplement designed to support cardiovascular, cognitive, and overall health. It also helps in managing healthy cholesterol levels in the body. Each softgel delivers a potent 750 mg of Omega-3 fatty acids, including 500 mg of Eicosapentaenoic Acid (EPA) and 250 mg of Docosahexaenoic Acid (DHA), sourced from select Peruvian and Chilean anchovy species recognized for their high Omega-3 content. This concentrated formula ensures that fewer capsules are required to achieve the widely recognized benefits of fish oil, making it a convenient addition to your daily wellness routine.

Product Details:

Form: Softgel

Type: Triglyceride

Dose: 1 softgels

EPA per Serving: 500 mg

DHA per Serving: 250 mg

Other Ingredients: Gelatin, glycerin, water, and d-alpha-tocopherol

Third-party Tested: Yes  


  • Subscription benefits: Save 15% now and on every additional shipment
  • Satisfaction Guarantee: Hassle-free 60-days money back offer
  • Enteric-coating is ideal for those who experience nausea or reflux from taking fish oil.
  • Free of potentially harmful levels of contaminants (e.g., mercury, heavy metals, PCBs, dioxins).
  • Natural vitamin E prevents the oxidation of fish oil.


  • Not ideal for pregnant women or those on medication.

 What Is Fish Oil?

Fish oil is a dietary supplement that is rich in omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These are essential fatty acids to develop and function optimally in every stage of life. These need to be consumed from external sources because the human body cannot produce them on its own. It is typically obtained from fatty tissues of fishes such as salmon, mackerel, sardines, herring, anchovies, and trout.

What makes fish oil supplements better than fish consumption?

1. Purity level: Fish oil supplements are purified to remove contaminants such as heavy metals and PCBs. e.g. ‘Minamata Disease of Japan’ occurs due to mercury poisoning leading to severe neurological and physical disorders in humans. It occurs due to the intake of contaminated seafood.

2. Dosage Control: Precise control over the amount of EPA and DHA you consume towards specific health goals or dietary needs.

3. Readiness: Convenient to purchase and suitable for consumption at any time of the day. Fish oil supplements can be taken in a hassle-free manner according to the recommendations of health providers.

Shifting our focus to fish oil supplements presents a strategic move. This transition not only enhances accessibility and flexibility but also serves as a gateway to exploring a diverse range of products in the realm of fish oil supplements. Let’s delve into the various offerings and benefits these products bring to the table. 

Problems With High Cholesterol

How does high cholesterol builds up in our body?

1. High cholesterol increases due to factors like a diet rich in saturated fats, lack of exercise, obesity, smoking, genetics, aging, medical conditions (e.g., diabetes), excessive alcohol, and stress.

2. Lifestyle changes, including a healthy diet and exercise, are key for management, along with medications if necessary.

3. Regular screenings and consulting healthcare professionals are crucial for effective control. 

Issues due to High Cholesterol:

1. Heart Attacks: Due to narrowing of arteries.

2. HyperTension: It could increase the strain on the heart and blood vessels.

3. Increased risk of clot formation

4. Stroke: Plaque formation could reduce blood flow to the brain and cause damage to brain cells. 

Benefits Of Fish Oil Supplements 

1. Heart Health: Omega-3 fatty acids in fish oil supplements may reduce the risk of heart disease by lowering blood pressure, reducing triglycerides, and improving overall cardiovascular function. The American Heart Association recommends fish oil supplements for individuals with coronary heart disease to lower the risk of sudden death and recurrent cardiovascular events.

2. Manage Cholesterol Levels: Omega-3 fatty acids present in fish oil supplements significantly reduce triglycerides and positively impact high-density lipoprotein (HDL) or good cholesterol in the human body.

3. Brain Function: Omega-3s in fish oil supplements support brain health, aiding cognitive function and potentially reducing the risk of neurodegenerative diseases. Research in the American Journal of Clinical Nutrition suggests that omega-3 supplementation may positively impact cognitive decline in individuals with mild cognitive impairment.

4. Joint Health: Fish oil supplements may alleviate joint pain and stiffness, providing relief for conditions like arthritis. The American College of Rheumatology recognizes the potential benefits of omega-3 fatty acids in managing symptoms of rheumatoid arthritis.

5. Eye Health: Fish oil supplements also improve eyesight. Omega-3s are essential for eye health, supporting the function of the retina and potentially reducing the risk of age-related macular degeneration. The Age-Related Eye Disease Study 2 found that omega-3 fatty acids, along with other nutrients, reduced the risk of progression to advanced age-related macular degeneration.

6. Inflammation Reduction: Fish oil has anti-inflammatory properties, contributing to the management of chronic inflammatory conditions. The American Journal of Clinical Nutrition published a study showing that fish oil supplementation reduces inflammatory markers in the body.

7. Improved Mood: Omega-3s play a role in mental health, potentially reducing symptoms of depression and anxiety. It also influences the production and activity of neurotransmitters like serotonin and dopamine which play key roles in mood control. The Journal of Psychiatric Research published a study indicating that omega-3 supplementation may have a positive impact on anxiety symptoms.

8. Skin Health: Due to the presence of EPA and DHA, Fish oil supplements may enhance skin hydration, reduce acne, and provide anti-aging benefits. 

9. Boosted Immune System: Omega-3s support the immune system, aiding in the body’s ability to fight off infections. Due to antioxidant properties, it neutralizes free radicals and hence maintains overall cellular health 

10. Pregnancy Benefits: DHA, a type of omega-3, is crucial for fetal brain development, making fish oil beneficial during pregnancy. Due to the purity level of fish oil supplements, it could be a better choice over fish consumption. However, it is advised to consult with healthcare providers. The Journal of Pediatrics published research indicating that higher maternal fish intake during pregnancy was associated with better neurodevelopmental outcomes in children.

11. Weight Management: Fish oil supplements may assist in weight loss by improving metabolism and reducing body fat. It also influences appetite hormones to regulate hunger and potentially reduce overeating. 

How We Choose The Best Fish Oil To Lower Cholesterol? 

Choosing the right brand for your fish oil supplement for cholesterol requires a lot of consideration and research. We have also curated this list by analyzing 50+ fish oil supplement for cholesterol brands, available on the market, on parameters like type, quality, lab tests, and more. Let’s discuss these parameters in length below.


It is important to understand the type of fish oil used in the supplement. Therefore, we have selected the supplements which feature omega-3 fatty acids, especially EPA and DHA. These omega-3 acids are known to offer effective results in decreasing the cholesterol levels in the human body.


Quality is the most important aspect of consideration of the best fish oil supplements for cholesterol. It is necessary to reduce the risk of contaminants such as heavy metals and pesticides in fish due to marine pollution.

This is why we have rated the top brands that feature proper certification and offer quality supplements by ensuring the procurement of fish oil from good quality fish. 


Third-party testing plays a vital role in ensuring the accuracy of ingredients listed on the labels. These tests also ensure that the high quality ingredients are used in the manufacturing. Therefore, while curating the list of the best fish oil supplements for cholesterol, we gave more importance to the brands that send their products for lab tests and transparency in the test results. 


It influences the quality of fish oil supplements for cholesterol. Cold-water fish like salmon, mackerel, sardines, or anchovies tend to have higher concentrations of omega-3s. Further, it is necessary to check whether your fish oil supplements are not threatening any type of fish species. Understanding this, we emphasized the brands that follow sustainable practices for ingredient sourcing and manufacturing of the products. 


While selecting fish oil supplements for cholesterol, we considered additional ingredients, such as natural lemon flavor, natural vitamin E, or enteric coatings, for potential benefits like reduced oxidation or aftertaste.

These ingredients help in enhancing the overall effectiveness and consumption of the supplement.


We compared the prices of different brands and analyzed them on the basis of cost per serving, dosage, and supply. We tried to pick the brands that offer cost balance with the quality and effectiveness of the fish oil supplements ensuring value for money.  

Fish Oil Supplements For Cholesterol: Comparison Table

ProductsPriceOffersDosageEPA per servingDHA per servingThird-party tested
Riti:Omega 3 fish oil softgels$44.95 for 1 bottle of 60 softgels/ $80.91 for 2 bottles/ $114.62 for 3 bottles25% discount upon subscription1432 mg268 mgYes
Life Extension: Super Omega-3 EPA/DHA Fish Oil, Sesame Lignans & Olive Extract$ 18.75 for 60 softgels15% discount on the product price upon subscription2500 mg700 mgYes
Care/Of: Omega-3 Fish Oil$ 16 for 30 softgelsN/A1500 mg250 mgYes
Nordic Naturals: Ultimate Oega-3s$29.95 for 60 softgels / $44.95 for 4-ounces/ $44.95 for 54 count gummiesSubscribe and save 10%2 softgels/ One-half to one teaspoon daily/ 2 gummies600 mg450 mgYes
Puritan’s Pride: Omega-3 Fish Oil Plus Cholesterol Support3 bottles contains 60 softgels each for $14.99 Discount of 66.67%2300mg  of        Fatty Omega-3s acidsYes
Nature Made1 bottle of 90 softgels for $14.89Discount of 10% on subscription2600 mg of         DHA EPA andservingYes
VitaMedica: Super EPA DHA Fish oil1 bottle of 60 softgels for$ 40Save 15% now and on every additional shipment1500 mg250 mgYes

FAQs About Fish Oil Supplements For Cholesterol

Q1. What is the best fish oil supplement for cholesterol?

Ans: There are several parameters that need to be considered while selecting the right fish oil supplement for cholesterol, including ingredients, price of the product, quality assurance, certification, and EPA and DHA level intake per serving. Abiding by all the parameters, Riti offers the best fish oil supplement. 

Q2. Do fish oil supplements lower cholesterol & blood pressure?

Ans: Yes, EPA and DHA present in the fish oil help in lowering levels of LDL(bad cholesterol) and increasing HDL(good cholesterol).Omega-3 also has been shown to reduce triglyceride levels. Omega-3 fatty acids also have a moderate effect on lowering blood pressure lowering effect, particularly in individuals with hypertension.  

Q3. When to take a fish oil supplement?

Ans: Fish oil supplements can be taken with meals as they will enhance absorption as dietary fats stimulate the release of bile and enzymes that aid in digestion and absorption of fat-soluble nutrients.

For two doses a day, there should be enough time between the two for absorption throughout the day.

Regular schedule for taking fish oil supplements for optimal results. 

Q4. Is there a difference between omega-3 and fish oil?

Ans: Omega-3 fatty acids cover a wide range of polyunsaturated fats that are essential for various bodily functions. It includes alpha-linolenic acid (ALA), EPA, and DHA. They can be made from the oils from flax seeds, fish, algae, krill, walnuts, and more, providing ALA.

On the other hand, Fish oil is a specific supplement that provides a concentrated source of EPA and DHA.

Q5. Are there any side effects of using fish oil supplements for cholesterol?

Ans: Fish oil supplements, while generally safe, may lead to side effects such as gastrointestinal discomfort, potential allergic reactions for those with fish allergies, mild blood-thinning effects, and, in extremely high doses, risks of vitamin A and D toxicity. Consultation with a healthcare professional is recommended, especially for individuals on medications, to manage potential side effects and interactions. 

Q6. How to add fish oil to your diet?

Ans: Fish oil can be incorporated into your diet by directly consuming fish such as salmon, mackerel, and sardines. However, due to marine pollution, there is a risk of contamination by heavy metals and PCBs. Therefore, consider fish oil supplements certified by a third-party agency, which prevents contamination and quality checks to counter any side effects. 

Q7. What are the dosage guidelines for fish oil to lower cholesterol?

Ans: Dosage guidelines for fish oil to lower cholesterol can vary, and it’s crucial to consult with a healthcare professional for personalized recommendations. Generally, a common dosage range might be 1,000 to 4,000 milligrams of combined EPA and DHA per day. Starting with a lower dose and gradually increasing it can help monitor individual tolerance and effects. Always follow healthcare provider advice for optimal results and safety.  

Q8. What are some other ways to lower cholesterol?

Ans: Cholesterol can be lowered by focusing on a plant-based or vegan diet and consuming healthy fats. Lifestyle changes, including regular exercise, maintaining a healthy weight, quitting smoking, limiting alcohol, increasing soluble fiber, consuming plant sterols, staying hydrated, considering green tea, including omega-3-rich foods, managing stress, and having regular health check-ups, can help you control cholesterol levels. Further, consult a healthcare professional for personalized guidance.  

Tailoring Your Approach: Fish Oil Supplements In Cholesterol Management

In conclusion, Fish oil is important for maintaining good health and body functionality. However, the market is diverse, and choosing the best fish oil supplement for individual needs is hard, and proper research is needed.

During our research, we noticed that Riti’s Omega-3 Fish Oil Softgels excel in EPA and DHA levels, and offer purity, potency, and quality.

In the end, tailoring choices according to individual needs, in addition to consultation with healthcare professionals, ensure optimal results in managing cholesterol levels and making the world fit by working with nature in a sustainable manner.

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