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Best Berberine Supplement Of 2024: Reviews, Benefits, Side Effects & More 

Tired of sifting through endless berberine brands, this article is a product of research on the best Berberine supplement for health management.
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Berberine, a relatively unfamiliar term for many, is a golden-yellow alkaloid compound extracted from plants and is known for its efficacy in controlling blood glucose and lipid levels.

Finding its origins in ancient Chinese medicine, berberine has become a new focal point due to its potential health benefits and is prominently featured in contemporary health and wellness discussions.

The increasing popularity of berberine has resulted in a saturated supplements market, making the task of choosing the most suitable berberine supplement a challenging one. In this article, we’ve examined various berberine supplements to compile a list of the best brands.

Within this selection, you’ll not only discover the best berberine supplements but also acknowledge them for their specific health benefits.

Best Berberine Supplement 2024: Summary Of Top Brands

  1. Overall Best Berberine Supplement: Riti 
  2. Best Berberine Supplement For Overall Wellness: Berbaprime
  3. High Quality Berberine Supplement For Blood Sugar Regulation: Berberine Pure
  4. Best For Maintaining Optimal Cholesterol Levels: Berberine HCL Powder
  5. Best Berberine Supplement For Glucose Management: Berberine Glucose Support
  6. Ideal For Potential Health Benefits: Berberine Special Formula
  7. All Natural & Vegan Dietary Supplement: Health Thru Nutrition

What Is Berberine?

Berberine is a yellow-colored, bitter-tasting alkaloid found in certain plants like barberry, goldenseal, and Oregon grape. Berberine has been used in traditional medicine to treat various ailments for its anti-inflammatory, anti-diabetic, and anti-microbial properties. 

Studies suggest that berberine may aid in weight management, cardiovascular health, and overall mental well-being. 

As a naturally occurring compound, berberine is increasingly explored for its therapeutic applications, making it a subject of ongoing research in the world of holistic medicine.

How Does Berberine Work?

Berberine exerts its beneficial effects through multiple mechanisms within the body. One key aspect is its ability to activate AMPK, an enzyme crucial in regulating cellular energy metabolism. AMPK activation enhances glucose uptake in cells, promoting improved insulin sensitivity and glucose regulation.

Moreover, berberine influences various molecular pathways, exhibiting anti-inflammatory and antioxidant properties. It inhibits the action of the PCSK9 enzyme involved in cholesterol synthesis, aiding lipid metabolism and supporting heart health.

Berberine impacts gut bacteria, altering the composition of the microbiome and potentially contributing to its antimicrobial properties.

Benefits Of Berberine Supplements

The reported research-backed benefits of Berberine supplements include the following:

  • Blood Sugar Management: Berberine supplements effectively regulate blood sugar levels, enhancing insulin sensitivity and reducing liver glucose production.
  • Cardiovascular Support: Berberine contributes to heart health by lowering cholesterol levels and protecting the myocardium.
  • Anti-Inflammatory Properties: Berberine exhibits anti-inflammatory effects, as research suggests its function in the inhibition of Nuclear factor, a major player in inflammation.
  • Weight Management: Studies suggest Berberine can help reduce weight in obese individuals by about 5 pounds.
  • Gut Microbiome Impact: Berberine modulates the diversity of gut microbes when taken at 500mg/day, promoting digestive health.
  • Anti-Cancer Effect: Some research indicates that berberine may have anti-cancer properties, showing promise in inhibiting the growth of certain cancer cells.

Review of The Best Berberine Supplement Brands

#1. Overall Best Berberine Supplement: Riti

Key Features:

  • All natural vegan-friendly ingredients
  • Third-party tested
  • Non-GMO 
  • Made in the U.S in an approved FDA facility

The Riti berberine supplement tops our list as it embodies the epitome of a successful dietary supplement. It ticks all the boxes that make a supplement effective – it’s affordable, goes through clear testing for safety, and offers a potent dose neatly packed in capsules for easy use.

With each bottle containing 60 capsules, Riti ensures a substantial intake of 1200 mg of berberine HCL per serving for 30 days, when taken at the recommended dose of 2 berberine pills per day shortly before meal. 

The primary ingredient, Berberine HCl from Berberis aristata, plays a pivotal role in improving insulin sensitivity, fostering a healthy liver, reducing glucose production, and facilitating the utilization of glucose and fats as energy sources for body cells.

Complementing this powerful blend, Riti incorporates rice flour, abundant in fiber, to impart a sense of fullness that aids in appetite suppression and curbing cravings. The inclusion of Magnesium stearate further amplifies the berberine supplement efficacy by enhancing the bioavailability of active compounds.

Riti’s berberine supplements notable potency and efficacy position it as an all-encompassing solution for adults seeking weight management, appetite control, and blood sugar regulation. 


  • All natural free from additives, fillers, and artificial ingredients
  • Aids in weight loss
  • Boosts mood and energy
  • Helps to promote healthy blood sugar levels
  • Improves liver health
  • 30-day money-back guarantee


  • Only available for purchase online

=> Click here to visit the official website “Riti”

#2. Best Berberine Supplement For Overall Wellness: Berbaprime 

Key Features

  • All natural vegan-friendly ingredients
  • Gluten free and non-GMO
  • Lab tested for purity and quality
  • ISO9001 and GMP certified
  • Made in the U.S in an approved FDA facility

If you’re after top-notch quality, Berbaprime is the go-to choice for berberine supplements. Berbaprime offers you a unique advantage by boosting the AMPK enzyme in your body—a vital regulator of your glucose metabolism. It also supports healthy cholesterol levels by reducing PCSK9 levels, an enzyme responsible for bad cholesterol storage.

Each bottle of  Berbaprime berberine supplement contains 90 veggie capsules of 1500 mg berberine HCL sourced from Berberis aristata. The formulation also incorporates microcrystalline cellulose, magnesium stearate, and silica, crucial components that enhance stability and bioavailability, ensuring an optimal experience tailored to your needs.

For optimal results, Berbaprime encourages you to take one capsule a few minutes before or with food three times daily.


  • Laboratory tested to ensure purity and quality
  • Free from gluten and lactose
  • Supports healthy metabolism
  • Authentic berberine derived from berberis aristata
  • 100-day money-back guarantee


  • A bit expensive, compared to other brands

=> Click here to visit the official website “Berbaprime”

#3. High Quality Berberine Supplement For Blood Sugar Regulation: Berberine Pure+

Key Features

  • All natural vegan-friendly ingredients
  • Gluten-free, non-GMO
  • Passed heavy metal testing, allergen testing, and third-party verification tests
  • Lab tested for purity and quality
  • GMP Certified
  • Made in the U.S in an approved FDA facility

Berberine Pure+ is another elite preference and a premium natural blood sugar formula meticulously crafted by Nuzena’s health experts. 

If you are battling with uncontrolled blood sugar and fat levels, Berberine Pure+ would provide dedicated support for a healthy metabolism, optimal blood sugar levels, and reduced bad cholesterol circulation in your system.

Derived from pure Berberine HCL sourced from Berberis aristata, this Berberine supplement is a targeted solution for maintaining your body’s sugar and cholesterol levels. 

Berberine Pure+ incorporates FDA-approved ingredients such as cellulose, rice flour, magnesium, and stearate to ensure a top-quality product. This guarantees the consistent absorption of berberine supplements, optimizing their utilization by your body.

Each Berberine Pure+ bottle contains 60 veggie capsules of 1200 mg berberine sourced from Berberis aristata. The recommended dose for Berberine Pure+ stands at two capsules taken once about 20-30 minutes before a meal.

You can take advantage of Nuzena’s limited-time offer and save up to 30% when you purchase 5 or more Berberine Pure+ packs.


  • Flexible Subscription plans
  • Laboratory tested to ensure purity and quality
  • Provides natural antioxidant support
  • Suitable for both men and women
  • 100% drug free
  • Comes with a free personal health specialist
  • Simple and easy returns 


  • It is only available in online stores.

=> Click here to visit the official website “Berberine Pure”

#4. Best For Maintaining Optimal Cholesterol Levels: Berberine HCL Powder 

Key Features

  • All natural vegan-friendly ingredients
  • Gluten-free, non-GMO
  • Lab tested for purity and quality
  • GMP Certified
  • Made in the U.S in an approved FDA facility

Berberine HCl Powder, a leading berberine supplement by Bulk Supplements, is specifically designed to help your liver, maintain optimal glucose and cholesterol levels and enhance heart conditions. 

This powdered formulation of berberine supplement, true to its name, offers an alternative to capsules for those with difficulty swallowing or who prefer versatility. 

Berberine HCL Powder by Bulk supplements comes in various sizes ranging from 25 grams to 25 kilograms, with each containing 500mg of pure Berberine HCl per serving, which is sourced from Berberis aristata.

With no additional ingredients, this berberine supplement remains straightforward and concentrated. Importantly, Berberine HCl Powder caters to vegans, aligning with diverse dietary preferences and restrictions. 

Berberine HCL powder allows for much flexibility in your dosing schedule as you can take anywhere between ⅕ tablespoon once or twice daily.


  • Free from yeast, sugar, gluten, additives, and dairy.
  • Contributes to a healthy digestive system
  • Promotes a healthy heart
  • Sustains healthy weight
  • Supports vision health
  • Maintains healthy bones


  • Flavor can be unbearable for some

=> Click here to visit the official website “Berberine HCL Powder”

#5. Best Berberine Supplement For Glucose Management: Berberine Glucose Support 

Key Features

  • All natural vegan-friendly ingredients
  • Diary and Gluten free 
  • Backed by scientific research
  • Lab tested for purity and quality
  • GMP Certified
  • Made in the U.S in an approved FDA facility

Berberine Glucose Support by Now Foods is a premium berberine supplement that is packed with 400mg of Berberine HCl, 238mg of Capric Acid, and 700mg of MCT Oil per serving to deliver a potent combination for maintaining optimal blood glucose levels.

Capric Acid being a key ingredient, addresses berberine’s bioavailability limitations in most berberine supplements and also provides gastrointestinal comfort, making it excellent for individuals with gastrointestinal issues. 

Berberine Glucose Support stands out with its unique additions like the anti-aging agent Beeswax, cholesterol-lowering Sunflower lecithin, and soft gel capsules made with bovine gelatin, glycerin, water, and caramel color. 

Each berberine glucose support bottle contains 90 softgels lasting for about 30 days when taken at the recommended dosage of one softgel taken with a meal three times daily.


  • Same day shipping options
  • Helps to support glucose and cholesterol levels
  • Contains anti-aging agent
  • 30-day money-back guarantee


  • Contains a low quantity of Berberine compared to others
  • Contains gelatin

=> Click here to visit the official website “Berberine Glucose Support”

#6. Ideal For Potential Health Benefits: Berberine Special Formula 

Key Features

  • All natural vegan-friendly ingredients
  • Diary and Gluten free 
  • Non-GMO
  • 100% PCR bottles
  • Lab tested for identity, purity, potency, and quality
  • GMP Certified
  • Made in the U.S in an approved FDA facility

Solaray’s Berberine Special Formula—is a meticulously crafted berberine supplement designed to address several health issues. Much like Berberine Pure+, it is designed to cater to adults with high blood sugar and staggering cholesterol levels.

In a study from 2017, it was discovered that 60% of tested berberine supplements did not meet the potency standards. However, Solaray employs an extraction process designed to guarantee a highly purified product.

Each bottle of Solaray contains 60 vegan-friendly capsules of 400 mg of pure berberine sourced from Indian barberry and Oregon grape (Berberis aquifolium). For optimal results, one capsule of Solaray’s berberine special formula should be taken with food once daily. 

Every product from Solaray, including the berberine special formula, is meticulously crafted in facilities that adhere to the stringent Good Manufacturing Practices (GMPs) mandated by the FDA.


  • Everyday promotions, offers, and discounts
  • Supports Digestive Health
  • Supports joint health
  • Contains vegan-friendly ingredients
  • 30-day money-back guarantee


  • Not available for offline purchase 

=> Click here to visit the official website “Berberine Special Formula”

#7. All Natural & Vegan Dietary Supplement: Thru Nutrition:

Key Features:

  • All natural vegan-friendly ingredients
  • Diary and Gluten free 
  • Lab tested for purity and quality
  • GMP Certified
  • Made in the U.S in an approved FDA facility

Unlocking the potential of natural ingredients such as Berberine HCL, Magnesium Stearate, Microcrystalline cellulose, rice flour, and other herbs, the Amazing Formulas Berberine 120 caps supplement is a groundbreaking solution designed to enhance the immune system and regulate blood sugar.

Developed by the Amazing Nutrition team, special attention has been given to ensuring that the Berberine supplement functions without disrupting other vital biological processes in the body.

This berberine supplement protects against the development of diseases by promoting cell expansion and modulating Treg and Th2 cells. Additionally, it plays a crucial role in controlling blood glucose levels by increasing the production of two key hormones – insulin and glucagon. These hormones work to reduce sugar cravings and limit the absorption of sugar in the gastrointestinal tract.

Amazing Formulas Berberine is particularly beneficial for individuals with weak immune systems or those struggling to control their blood sugar levels. The recommended dose for Amazing Formulas berberine is two capsules to be taken with a meal once daily.


  • Worldwide shipping
  • Supports Cardiovascular & Gastrointestinal Function
  • Supports immunity function
  • Improves insulin sensitivity
  • Coupon codes for special discounts


  • Only available for online purchase

=> Click here to visit the official website “Amazing Formulas Berberine 120 caps”

How To Choose The Best Berberine Supplement?

So far, we’ve covered a lot of things, but it’s time for some exclusives. How did we come about our list of the best Berberine supplements? Here are the factors we took into consideration:

  • Ingredients

We examined the ingredient list of the best Berberine supplements thoroughly. A quality berberine supplement should contain pure berberine extract without unnecessary additives or fillers. We also ensured the source of berberine was clearly mentioned, indicating whether it is from plants like Berberis aristata or goldenseal.

  • Dosage

The best berberine supplements, such as those featured on our list, offer optimal dosages in line with scientific research (400 – 1500 mg). Inadequately high or low doses may prove ineffective or carry potential risks of toxicity.

  • Brand Reputation

We ensure that all our picks are certified, lab-tested, and third-party tested, and they also offer a money-back guarantee. These are a few ways to confirm authenticity.

  • Pricing

We ensured their pricing matched their quality. However, pricing always depends on budget, which doesn’t mean you should settle for less. We selected the brands that offered quality supplements at affordable prices without compromising on anything.

  • Customer Reviews

Although individual responses may vary, it’s paramount to check customer reviews to gain experience on how the product is faring. Thus, we checked umpteen customer reviews from several websites to find the best Berberine supplements.

What Is The Most Effective Form Of Berberine?

There is no gold standard for this; all berberine forms are effective, although it all comes down to bioavailability, which is the amount available for use by the body after a series of absorptions. 

While Berberine HCL is the widely used form, it is often not commonly available for the body to utilize, as some are lost during absorption. Hence, top brands like Riti reinforce it with magnesium stearate, with the sole responsibility of making Berberine HCL available for utilization by the body. 

Other more readily available berberine forms include Dihydroberberine, Berberine sulphate, Berberis aquifolium, and Berberine citrate.

How Much Berberine Should Be Taken In A Day?

The wonderfulness of Berberine supplements may tempt you to take more than the recommended dosage, but it’s crucial to resist exceeding the recommended dose provided by the manufacturer or healthcare provider.

The American Association of Naturopathic Physicians (AANP) recommends a daily intake of 400 to 1500 mg of Berberine supplements, either as a single dose or divided into 3 or 4 doses. For optimal results, it is advisable to take the supplement with or shortly after meals to minimize the spike in Glucose and or Lipid levels associated with food digestion.

And, as with all supplements, always check with your healthcare providers before incorporating Berberine supplements into your lifestyle.

Who Should Avoid Taking Berberine Supplements?

As important as Berberine is to maintain good overall well-being, some individuals should exercise caution or avoid taking Berberine supplements. They include:

  • Pregnant/Nursing women
  • Children
  • People on certain medications like sedatives and anti-coagulants to avoid drug-to-drug interactions

You can always check with your healthcare provider to ensure safety.

FAQs About Berberine Supplements

Q1. What is berberine used for?

Berberine is a one-stop solution for multiple health issues, including managing blood sugar levels, promoting cardiovascular health, weight management, supporting liver health, reducing free radicals, managing inflammation, and improving digestive and gut health.

Q2. What are the side effects of using berberine supplements?

Berberine supplements, when abused by a healthy individual, may cause side effects such as gastrointestinal discomfort, including cramping, diarrhea, and constipation. Some people may experience headaches or allergic reactions. These effects typically fade as your body adjusts to the dosage and usually don’t require medical attention. However, if you experience serious or rare side effects, seek medical attention.

Q3. How long does it take to see results from berberine?

The time to see results from berberine varies due to individual genetics. Some individuals may notice improvements in blood glucose and lipid levels within a few weeks to months, while others may take longer. Consistent use, coupled with a healthy lifestyle, is key to optimal outcomes.

Q4. Can berberine really reverse fatty liver?

Yes, Berberine has been shown to alleviate liver fibrosis by modifying lipid metabolism. Both pharmacological and clinical evidence strongly support the effectiveness of Berberine in treating metabolic conditions, such as non-alcoholic fatty liver disease and hyperlipidemia

Q5. Which foods contain berberine?

Berberine is naturally present in foods such as barberries, goldenseal, Chinese goldthread, and Oregon grape. Barberries, with their tart taste, are a rich source, along with the medicinal herb goldenseal. Chinese goldthread’s rhizomes and the small Oregon grape berries also contain berberine. Turmeric, though in smaller amounts, provides additional berberine.

Q6. Do berberine supplements help in weight loss?

Yes, Berberine supplements may aid weight loss by influencing the metabolic process. Studies suggest that berberine can enhance insulin sensitivity, regulate blood sugar levels, and affect lipid metabolism, potentially reducing body weight.

Q7. Is berberine as effective as metformin?

Berberine has shown comparable effectiveness to metformin in managing blood sugar levels. Studies suggest berberine’s ability to improve insulin sensitivity and regulate glucose metabolism, making it a viable natural alternative to metformin for some individuals.

Concluding Thoughts: What Is The Best Quality Berberine On The Market?

Berberine’s multifunctionality in addressing various ailments has a well-established history, dating back as far as 300 years in traditional medicines. The benefits of this natural compound are now explored through berberine supplements. 

Amidst the saturated market, Riti stands out as the best, boasting a trifecta of advantageous qualities: affordability, transparent testing and safety measures, and a potent dosage encapsulated for optimal function.

Though berberine provides various health benefits, it’s vital to recognize potential side effects and interactions. As is the case with any supplement, consulting with a healthcare professional is crucial to ensure it aligns with your specific health needs.

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