With 3-D printing, you can produce just about anything— from simple household items to human stem cells. Sorrento Mesa-based biotech company Organovo is taking it one step further and printing miniature livers, kidneys, and other tissues.
It’s tempting to imagine a future where solid human organs can be engineered in a lab, and potentially help end the shortage of donor organs. (In the U.S., 22 people die each day waiting for an organ.) But while complete organs ready for transplant are likely more than a decade away, Organovo’s micro-livers have some exciting immediate advantages. For one, they respond to drugs like real livers—which means they can be used by pharmaceutical companies to test the safety of new medicines.
“We have shown multiple drugs—that were not seen to be toxic, based on studies in rats and 2-D hepatocytes, but then had costly problems in late-stage human trials—to have a clear toxicity in our tissue,” says Keith Murphy, cofounder and CEO of Organovo. “This is an opportunity to really understand, in a much better way, how a drug is going to work in humans.”
The company is also printing tiny tumors, made with cells from actual cancer patients. Just like with the mini-livers, the idea is to give drug companies a better way to test new therapies. As Murphy points out, without the tools to see how a drug will react with cancer cells in humans, there is no next step in cancer therapy. The idea is that the tiny tumors engineered in Organovo’s lab will eventually provide that next step.
You know the tuna I’m talking about. It’s easy to mistake for a cube of watermelon. It’s the color of a Lyft logo. Appears to be glowing a vibrant, tantalizing purity. Tuna that bright red or pink means it’s… what, extremely fresh? Bursting with nutrients?
I thought this was widely known, but a chef recently told me very few of his staff members were aware of this, and almost none of his customers. So, especially with the recent proliferation of poke joints, I thought I’d be helpful with this PSA of sorts.
Bright red or pink tuna means it has been gassed. In its natural state, fresh tuna is dark red, almost maroon, sometimes even chocolatey-looking.
But here’s why I personally tend to back away when I see bright red or pink tuna:
1. IT’S MUCH HARDER TO TELL IF IT’S FRESH OR NOT.
It can be left out for days and it will not turn brown. In one study, the University of Florida found that carbon monoxided tuna kept its bright red color for 11 days in the fridge. “The carbon monoxide actually hides the quality of a fish,” says Tommy Gomes, fifth-generation San Diego fisherman, host of The Fishmonger on Outdoor Channel, and owner of seafood shop Tunaville in Point Loma. “It’ll make a poor-quality fish pretty like a rose. I’ve seen them take an old piece of brown tuna [and] put the gas on it, and it comes out looking like cherry lemonade.” The gas also masks the smell of old tuna (which is one way you can tell if tuna’s getting past its eat-by stage). “Since there’s no smell, it falsifies the freshness,” Gomes explains.
2. I TRUST GOVERNMENT HEALTH ORGANIZATIONS, BUT ALSO RECOGNIZE THEY’RE NOT PERFECT.
The 1992 USDA food pyramid suggested carbs should be the bulk of our diet (they corrected that in 2005 and 2011). The government approved the fat substitute Olestra, which gave people all sorts of tummy issues. Margarine and other trans fats were also approved, then banned in May 2019. There are some smart humans in the government, but even geniuses make mistakes. So I tend to go with my gut: tuna in its natural state, or tuna treated with carbon monoxide? Easy choice.
So why gas tuna at all? Because of us. Consumers don’t like brownish fish. Tuna oxidizes quickly. It’s difficult for tuna fishermen and women to get it to market quick enough before it turns that brownish or chocolatey color. Customers erroneously think all brownish-looking fish is old or bad and will pay more for “fresher-looking” fish. So in the 1990s, the FDA allowed companies to gas the tuna and keep it artificially bright red for long stretches at a time.
“There’s nothing wrong with a hot chocolate–looking tuna loin,” says Gomes. “But, here in America, we want [it] seared on the outside, rosy pink on the inside.”
What fresh tuna should look like
Gassed tuna is also often imported and less inexpensive than fresh, un-gassed tuna, says Gomes. “So, to be fair and honest,” Gomes acknowledges, “for families on a budget, gassed tuna is one of the best alternatives out there for frozen seafood.”
In theNew York Times article cited above, a sushi restaurant owner reported his sales of tuna tripled when he started using gassed tuna. So that’s obviously good for the small business owner, as well as grocery stores. Food waste is a massive epidemic—the US throws out about half of edible seafood. If gassed tuna gets Americans to eat perfectly edible tuna they otherwise might throw out, that’s a step in a good direction.
But it’d be better if we as consumers knew that fresh, non-gassed tuna is supposed to be dark red or maroon—not bright red or watermelon pink, like a majority of the tuna I’ve seen at local poke shops. Ideally, we would look at a piece of bright red/pink tuna and think “Oh, hey there, carbon monoxide.”
The most important things about buying tuna is to trust the source (whether grocery store, fishmonger, or sushi joint). It also should be shiny and somewhat translucent, and not have slime or an off-smell.
Troy Johnson is the magazine’s award-winning food writer and humorist, and a long-standing expert on Food Network. His work has been featured on NatGeo, Travel Channel, NPR, and in Food Matters, a textbook of the best American food writing.
Today’s seniors are more connected than ever, with a renewed focus on retirement as a time of discovery and enriching experiences. The ultimate reward for a retirement well-earned is the wisdom to appreciate it all, and what better place to enjoy that unique perspective than Vi at La Jolla Village, in the heart of San Diego.
All-access pass to good living.
As a Continuing Care Retirement Community (CCRC), Vi provides access to a connected and fulfilling community while making it easy to plan for future care, should the need ever arise. With a care plan in place, residents enjoy greater financial predictability and long-term value, freeing them to focus on making the most out of retirement.
Resort-style amenities at the epicenter of a cultural hub like San Diego offer a retirement experience unlike any other. Paired with exceptional dining, spacious accommodations and dedicated staff, the best of maintenance-free living is all around. And with the introduction of Vista 360 Well-Being, Vi’s panoramic approach to wellness, there are more ways than ever for residents to access it all.
The harmony of mind, body and community.
Courtesy of Vi at La Jolla Village
The key to longevity is striking the right balance in maintaining an active lifestyle with an active mind in a fulfilling community. With newly renovated community spaces and restaurants, Vista brings a variety of opportunities for residents to elevate their well-being through Vi-exclusive “Signature Experiences.”
Vista Enrich takes an evidence-based approach to brain vitality, keeping residents at the forefront of cognitive health through exergaming (exercising + gaming), nutritional plans and informative workshops. It is also home to The Brain Vitality Studio, an innovative facility dedicated to cognitive fitness that has garnered national recognition.
Vista Discover invites residents into stimulating educational experiences, from chef-led cooking demos and guided wine tastings to lectures at local universities and intimate lectures following cultural outings.
While Vista Enrich focuses on brain health and Vista Discover engages residents intellectually, Vista Explore cultivates a sense of adventure through curated travel and local excursions. But broadening one’s horizons doesn’t always require a plane ticket. One recent event brought a taste of the world right to the community: an onsite “jazz cruise” featuring live music and global cuisine served at a series of themed “ports” all within the community’s own ballroom.
“Location, location, location”
Courtesy of Vi at La Jolla Village
One of the biggest perks of life at Vi at La Jolla Village is its proximity to just about everything. With easy access to transportation and local attractions just steps away, residents can explore and engage with their community at their own pace.
“There are trolley and bus stops within a 5-minute walk that will get you to the beach, UCSD Campus, medical appointments, downtown La Jolla or San Diego, et cetera. We rarely use our car,” said resident Tom Yager.
With the best of San Diego just steps away, residents don’t just live in the city, they live within reach of everything that makes it special.
The best of all worlds.
Courtesy of Vi at La Jolla Village
At Vi at La Jolla Village, retirement isn’t a chapter to slow down; it’s an invitation to discover more. Tailored community experiences created by Vista, paired with the vibrant pulse of San Diego just outside the door, mean that residents don’t have to choose between security and adventure, connection and independence. They get all of it.
This is what an all-access pass to good living looks like: the comforts of an elevated lifestyle, a community built for growth and a city made for discovery – all in one place.
To learn more about Vi at La Jolla Village or for details on available floor plans, visit ViatLaJollaVillage.com/SDM.
Growing up, Laika Nur, MD, Scripps Clinic sports medicine specialist, loved watching beach volleyball when the Association of Volleyball Professionals tour came to her hometown of Chicago. A talented volleyball player herself, she remembers sitting in the stands all day, and once, even got a couple autographs. Years later, Dr. Nur was attending a professional event focused on women’s sports, and the discussion turned to a new professional women’s volleyball league. The general manager and coaching staff for San Diego’s team, the Mojo, happened to be in attendance, and Dr. Nur took the opportunity to ask them if they needed a team doctor. Flash forward to the Mojo’s inaugural 2024 season, when Dr. Nur officially became the team physician. Click here to read more about Dr. Nur and how she incorporates lessons she learned on the court into her practice.
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